OXTR-Targeted Drug Discovery Services

Introduction

The oxytocin receptor is also known as OXTR. It is encoded by the OXTR gene. The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]

Direction of Drugs Discovery

• OXTR Agonist
• OXTR Modulator
• OXTR Inhibitor
• OXTR Antagonist
• Developing New Clinical Effects on OXTR from Existing Drugs

Drugs

• OXTR Agonist- Desmopressin, carbetocin, FE-202767, [Phe3]OT
• OXTR Modulator- Oxytocin, retosiban
• OXTR Inhibitor- ATOSIBAN, SSR149415, PF-3274167, L-371257
• OXTR Antagonist- Barusiban, GSK-557296, PMID28906174-Compound-figure1g

What We Offer

Target Testing

CD BioSciences provides OXTR testing services by ELISA, WB, IF, ICC, or IHC assay. The results of OXTR testing are used to evaluate the activities of candidates against OXTR or targeted diseases. You can choose one or more testing ways to detect the level of OXTR according to your experiment.

Hit Identification (show more)

The goal of early drug discovery is to find novel lead compounds that have the desired potency, selectivity, and ADMET properties for pre-clinical evaluation.
CD BioSciences offers hit identification services to make your finding of targeted compounds more successful and faster.
• High-Throughput Screening
• OXTR-Targeted in Silico Virtual Screening
• Fragment-Based Screening
• High-Content Screening

Antibody Drugs Development Services (show more)

Antibody drugs exhibit many incomparable advantages, such as high specificity, affinity, and efficiency, which is an emerging direction on targeted drug development. CD BioSciences provides comprehensive services on OXTR-targeted antibody drugs development with professional technology, extensive experience, and advanced equipment.
• Antibody Preparation Services
• Phage Display Services
• Antibody-Drug Conjugates
• Bispecific Antibody Services
• Antibody Humanization Services

Pharmacological Experiments (show more)

We will create a specific experimental plan according to your requirements, including but not limited to
• Pharmacokinetics / Pharmacodynamics
• Pharmacodynamics
• Pharmacokinetics
• Safety Pharmacology

Disease Models Screening (show more)

We will create specific disease models to accelerate your targeted drug discovery project, including but not limited to
• Diseases—Postpartum haemorrhage, diabetic complication, preterm labour, anxiety disorder, etc.
CD BioSciences will establish the specific disease models according to your requirements to evaluate the inhibitory activity of your candidates targeted OXTR. We have various cell lines and the species of our animal models cover rats, mice, rabbits, dogs, and non-human primates.

Inquire Us

References

1. Stelzer G.; et al. The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analysis , Current Protocols in Bioinformatics(2016), 54:1.30.1 - 1.30.33.doi: 10.1002 / cpbi.5.
2. Wishart DS; et al. DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue): D901-6.
3. Y. Zhou; et al. Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents. Nucleic Acids Research. 50(D1): 1398-1407 (2022). PMID: 34718927.