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Pharmacokinetics and pharmacodynamics are two broad divisions for targeted drug discover project. In briefly, pharmacokinetics is to study the movement of drugs within the body, while pharmacodynamics is associated with the effects of drugs and the mechanism of their action. Both pharmacokinetics and pharmacodynamics play a crucial role in determining a drug's safety and efficacy. CD BioSciences offers comprehensive services on studies of pharmacokinetics and pharmacodynamics to accelerate your targeted drug discovery project.
Pharmacokinetics/ pharmacodynamics together can be thought of as an exposure/response relationship. It is an important data to evaluate the effect and safety of drugs. Drug developers use insights gained from PK and PD analyses to design better clinical studies. Clinicians use the information from PK and PD analyses to treat different types of patients.
Pharmacokinetics describes a drug's absorption, distribution, metabolism, and excretion (namely ADME), and is what the body does to the drug. It describes a drug's exposure by characterizing its ADME properties and bioavailability as a function of time.
Pharmacodynamics is associated with the effects of drugs and the mechanism of their action. The study on drug effect is an essential process for candidate discovery. According to the classification and pharmacological characteristics of candidates, in vitro and in vivo models are used to reflect the main pharmacodynamic effects of these candidates. The pharmacodynamic assays included in the evaluation of the drug efficacy is very important, which should be initiated at very early stage, for supporting drug discovery and development efforts.
Safety pharmacology is relative to study the potential undesirable pharmacodynamic effects of a substance in relation to dosage within the substance's therapeutic range and above. Assessing any potential adverse effects and potential life-threatening risks is a crucial step for drug development.
