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MAPK15 is an atypical member in MAPK family. The studies on MAPK15 are few, while many results indicated that it is concerned with various cellular pathways and the abnormal expression of MAPK15 is associated with cancer development. The functional significance of some of these interacting proteins was more characterized whereas some are barely studied, yet further study should be conducted to discover the consequence of these interactions.
Mitogen-activated protein kinase 15 (MAPK15), belonging to MAPK family, is an enzyme that in humans is encoded by the MAPK15 gene located on chromosome 8q24.3. It is also called as ERK7, or ERK8, while at least one study has indicated that the two proteins are different, in fact. MAPK15 exists in many tissues and there is the highest expression in lung and kidney. Recently studies suggested that MAPK15 plays important roles in diverse cellular events including cell division, ciliogenesis, cell proliferation, cell transformation, apoptosis, autophagy, and genome stability. Besides, it participates in cancer development. The abnormal expression was observed in many cancers.
Unlike other typical MAPKs that require sequentially activating kinases, MAPK15 can be autophosphorylated and few direct upstream activating kinases have been identified so far. MAPK15 can be activated by serum, DNA damage, H2O2 treatment, and human oncogenes. It can interact with a diverse class of protein molecules in various subcellular localizations from extracellular space, plasma membrane, cytoplasm, to the nucleus, while the detailed mechanism is unclear. MAPK15 participates in a variety of cellular activities, such as promoting cell proliferation, cell transformation, and apoptosis; stimulating autophagy; regulating cell division, ciliogenesis, and protein secretion; and maintaining genome stability. The role of MAPK15 in cancer development is still unclear. MAPK15 is regarded as an oncogene in male germ l tumors, colon cancer and gastric cancer, while other studies indicated that it also maintains genome stability and suppresses tumorigenesis in mammary and lung tissues. More studies need to conduct in order to reveal the mode of action of MAPK15 on physiological and pathological processes.
Approved Drugs
Fostamatinib.
Spleen Tyrosine Kinase Inhibitor
Fostamatinib.
Embryo-fetal mortality, developmental abnormalities, hypertension, neutropenia, diarrhea, and hepatotoxicity.
MAPK15 TestingCD BioSciences provides MAPK15 testing services by Elisa, WB, IP, IHC or IF assay. The results of MAPK15 testing are used to evaluate the activities of candidates against MAPK15 or targeted diseases. You can choose one or more testing ways to detect the level of MAPK15 according to your experiment.
Hit Identification (show more)The goal of early drug discovery is to find novel lead compounds that have the desired potency, selectivity, and ADMET properties for pre-clinical evaluation.
CD BioSciences offers hit identification services to make your find targeted compounds more successful and faster.
Pharmacological Experiments (show more)We will make a specific experimental plan according to your requirements, including but not limited to
Disease Models Screening (show more)We will make specific disease models to accelerate your targeted drug discovery project, including but not limited to
CD BioSciences will establish the specific disease model according to your requirements to evaluate the inhibitory activity of your candidates targeted MAPK15. We have various cell lines and the species of our animal models cover rats, mice, rabbits, dogs, and non-human primates.
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